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Finally, elevated levels of dopamine and symptoms of gastroesophageal reflux have recently been described as important contributors to difficulties in maintaining sleep and insomnia (38, 39).
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Complexity of neurological diagnoses and basic neuroscience was also rated among the top five contributors to difficulty of neurology, in agreement with findings from the UK and Ireland [ 4, 6].
Obstructive sleep apnea (OSA) is often a contributor to difficulties in managing the upper airway and ultrasound measurement of the width of the tongue base has been found to correlate with the severity of sleep-related breathing disorders, including the patient's sensation of choking during the night [15].
Inspiratory muscle weakness is a known consequence of mechanical ventilation and a potential contributor to difficulty in weaning from ventilatory support.
Ventilator-induced diaphragmatic weakness is clinically significant because diaphragmatic dysfunction can be an important contributor to weaning difficulties.
Others have described rurality as a contributor to the difficulties of service provision, for example in maternity services [ 18] and in provision of nursing services [ 19].
This has been one source of toxicology's present difficulties and a major contributor to the difficulty of resolving controversies.
A major contributor to the difficulty of identifying and developing effective treatments, aside from delayed diagnosis, is the complex non-cell autonomous nature of the disease.
Notably, neuroanatomy was a smaller contributor to the difficulty of neurology for residents compared to students.
The need to know basic neuroscience was identified as the biggest contributor to the difficulty associated with neurology (3.89 ± 0.072) followed closely by the complex clinical examination associated with neurology (3.69 ± 0.072).
Pregnancy can be a potent contributor to ventilation difficulty because of edema of the upper airway tract, and motion limitation of the thorax and diaphragm may occur unexpectedly [ 9– 11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com