Exact(9)
Authors' contributions: Study design: RJ and JJP.
Contributions, Study 1 (PK/PD study): Project design: PLT, EJ, MS, FW.
Specific author contributions: Study design: S.P. and J.W.; assays: G.B., T.D., S.P.; analysis: S.P. and J.W.; review of draft: all authors.
Guarantor of the article: Manuel Perucho, Ph.D. Specific author contributions: Study design: A. Leodoloter, S. Alonso, and M. Perucho; Patient recruitment: A. Leodolter, M. PA.
Specific author contributions: Study design: ME and OW; data collection: LL, EH, and JG; data analysis and interpretation: LL, MK, OW, EL, and ME; manuscript drafting: LL, EL, and ME; critical revision of the manuscript: OW, PK, and HG; statistical analysis: MK and LL; obtained funding: OW, HG, and ME; and study supervision and patient inclusion: AL, PK, IJ, and RB.
Specific author contributions: Study concept and design: N.N., G.F., U.G., Y.F., J.F., A.W.; acquisition of data: N.N., T.B., E.L., O.S., I.H., I.J.-P., M.N., U.G., J.F., A.W.; analysis of data and drafting of the manuscript: N.N., G.F., U.G., Y.F., J.F., A.W.; funding: A.W. and J.F.; study supervision: A.W.; review of draft: all authors.
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