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Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
The genetic contribution to variation in lipid-lowering response to statin treatment appears to be influenced by multiple loci with small individual contributions that are compounded when jointly inherited.
In addition, it would also be important to evaluate the impact on population-specific variation of balanced rearrangements not detected by aCGH, such as inversions, that, although putatively less frequent, could have a total genome coverage and potential contribution to variation at least as important as that of copy number changes [36], [37].
To this end, the CEPH model system was used to a) assess variation in response to the camptothecins across normal healthy human LCLs, b) evaluate the genetic contribution to variation in response and c) establish a pattern of multiple QTLs common to a class of drugs suggesting a shared mechanism of action.
The genetic contribution to variation was relatively high for some traits for instance, 10th rib backfat with around 250 SNPs likely accounting for 54% of total genetic variance (µ = 0.995), loin muscle area with the same number of SNPs accounting for 55%.
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Its heart is its second movement, "A Lament," Tippett's contribution to "Variations on an Elizabethan Theme," a 1952 project for which several British composers wrote movements to celebrate the impending coronation of Queen Elizabeth II.
Changes in precision values also had a major contribution to variations in MCC – they were even more visible due to the range of MCC from −1 to 1.
Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N = 53,949).
Evolutionary psychologists emphasize the biological contributions to variation, dual-inheritance theorists emphasize bio-cultural interactions, and their critics suggest that the human capacity for cultural transmission reduces the import of biology.
Principal Component Analysis (PCA) was used to determine the main contributions to variation in the data.
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