Sentence examples for contribution to normal from inspiring English sources

All these studies highlight that, except for those focusing on single or a reduced number of loci [43] [45], more detailed analysis of the loci is necessary to determine their potential contribution to normal phenotypic variation and disease susceptibility.

Further experiments are needed to confirm these structures in vivo and establish their contribution to normal and pathological mitochondrial biology.

Although protein aggregation is well studied in the context of neurodegenerative diseases, its contribution to normal aging is poorly defined.

Understanding the maintenance of mtDNA integrity and its contribution to normal cellular survival is vital to unraveling human mitochondrial diseases.

With regard to coupling of the molecular clock to cell cycle and DNA damage checkpoints, while the coupling does exist, its contribution to normal cell physiology is limited and not essential.

Twin and family studies have consistently estimated that the additive genetic contribution to normal variation in adult height approximates 80% in a given population at a given time [ 7- 9].

There is growing recognition that B cell contributions to normal immune responses extend well beyond their potential to become antibody-producing cells, including roles at the innate adaptive interface and their potential to modulate the responses of other immune cells such as T cells and myeloid cells.

In essence, applying targeted gene knockdown for individual Ras isoforms in zebrafish will help clarify their distinct mechanisms, establish their relative contributions to normal physiological functions, and further analyze their potential downstream pathways.

Although a small number of the vast array of animal long non-coding RNAs (lncRNAs) have known effects on cellular processes examined in vitro, the extent of their contributions to normal cell processes throughout development, differentiation and disease for the most part remains less clear.

Six of the 23 genes we identified had quite low penetrance effects on gastrulation, and higher penetrance in ced-5 (n1812 ), and 13 could only be implicated in combination with ced-5 (n1812 ), suggesting that many of these genes may act redundantly or partially redundantly in gastrulation, or in separate processes that make indirect contributions to normal gastrulation.

The vagina makes a major contribution to the normal female sexual response cycle.