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Moreover, for eletriptan and rizatriptan, the presence of an active metabolite was not taken into account, as its contribution to efficacy is reported to be low.
In this line, it would be helpful to identify which surrogate markers may help us to predict this contribution to efficacy.
2, 3 However, there is uncertainty as to the clinical importance of reduced bioavailability of lumefantrine when taken without fatty food, 4– 8 especially with evidence of resistance to artemisinin derivatives in adjacent Cambodia increasing the required contribution to efficacy by the partner drug.
In view of the previous phase 2 data with bevacizumab monotherapy in untreated patients, 42 in which a median PFS in excess of 9.0 months was noted, it is reasonable to suggest the major contribution to efficacy in terms of PFS improvement, may be secondary to this agent.
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It was previously reported that the contribution to clinical efficacy varied between the 5-HT1B and 5-HT1D receptors[37].
It indicated that the heterogeneity of genome profiles may have had a great contribution to the efficacy of breast cancer treatments.
This indicates that ER-α correlated genes make a significant contribution to the efficacy of the predictive gene lists in these data sets (figure 2C).
Lastly, the potential contribution to formulation efficacy (FEMIC or FEMFC reflecting individual compound antifungal activity vs. in a formulation; See Methods) of the individual compounds was calculated to be high (H) (FEs ≥ 4) for cinnamaldehyde, o-vanillin, 2-hydroxy-5-methoxybenzaldehyde, 2,3-D and thymol in almost all cases (Table 4).
When the job-related factors were entered in the second step, the safety climate and the physical job demands provided a significant contribution to self-efficacy, and the variables added explained an additional 20% (p < 0.001).
However, when focusing on the different therapeutic elements and their individual contributions to clinical efficacy, some questions arise.
Though that group contained a small number of subjects, the importance of investigating a new program contribution to FPs self-efficacy for future research was evident.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com