Sentence examples for contribution the binding from inspiring English sources

In the present contribution, the binding of two chemically closely related human aldose reductase inhibitors had been studied by high-resolution X-ray analysis (0.92 1.35 Ǻ) and isothermal titration calorimetry against a series of single-site mutants of the wild-type protein.

Then temperature contribution can be obtained In order to calculate binding polynomial contribution the binding polynomial P j for each reactant j should be first calculated (7): (A.12) where K di is the dissociation constant of cation ion d.

The non polar contributions to the total solvation free energy and the molecular mechanical internal energies have a less significant contribution to the binding.

Further studies showed that the hydrophobic interactions made the dominant contribution to the binding free energy.

It was found that the van der Waals repulsion makes the dominant contribution to the binding energy.

Furthermore, these extrapolations are not expected to be normal for such molecules in which ionic forces make an appreciable contribution to the binding.

Hydrophobic and aromatic interactions are fundamental as well, but are ligand-dependent, varying mainly according to the ligand size: the hydrophobic contribution to the binding of smaller molecules, as coumarin, is lower.

Modeled on an analogy to a liquid drop, the first term represents the favourable contribution to the binding of the nucleus made by short-range, attractive nuclear forces between neutrons and protons.

The strongly favourable enthalpic contribution for the binding of ANS to Sj26GST is compensated by a negative entropy change, due to enthalpy-entropy compensation.

One way to circumvent this problem has been implemented with antibody systems, where contribution to the binding site is provided by two different polypeptides (light and heavy chains).

The binding energies exhibit a strong linear correlation to the magnitude of the solute's displacement towards the vacancy, suggesting that local lattice relaxation is a significant contribution to the binding energy.