Key aspects for such research include the importance of squamous histology and the contributions of vessel permeability, hypertension and vessel wall erosion.
Because of signal suppression due to T2prep, only little signal contribution of the vessel wall can be expected.
Despite placement of nicardipine pellets around the middle cerebral artery to minimize proximal vasoconstriction, spontaneous depolarizations still occurred in 10 of 13 patients [ 27], casting further doubt on the exact nature of the contribution of proximal vessel constriction to DCI.
To investigate the contribution of PMCA, vessels were pre-treated with 10 μM of the PMCA inhibitor CE (Fig. 4d f).
Given that the subintestinal plexus has been regarded as one of the possible origins of the GI tract vasculature, we decided to investigate the relative contribution of surrounding vessels to its formation, using photoconversion of ECs (Fig. 2; Fig. S1).
Emerging evidence for the potential co-contributions of small vessel vasculopathy to dementia has resulted in a more nuanced view of Alzheimer's disease (AD) pathogenesis.
However, using SAM to resolve the individual mechanical contributions of discrete vessel sub-structures [18], we identified significant changes in acoustic wave speed that were localized to the inter-lamellar regions of the medial layer.
The corresponding vessel diameter changes are given in Fig. 4C, to help identify the contribution of velocity and vessel diameter to the reduced blood flow rate.
An SE-EPI sequence with an additional gradient can remove the contribution of large blood vessels to BOLD signal, because diffusion effects are small around large blood vessels, and the velocity in the vessels is high [ 13, 16].
Parallel imaging and histological studies are needed to evaluate the contribution of persistent immature/mature vessels to disease progression and may illustrate the specific pathogenetic contribution of immature vessels.
