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The rate of l-Arg uptake by RBC treated with 40 μM FP is reduced by ∼40% independent of the incubation time (Fig. 5 B ). From the values reported in Fig. 6 A corrected for the diffusion component, it was calculated that contribution of systems y+ and y+L to the total transport was about 68% and 17%, respectively, in control RBC and 72% and 7% in FP-RBC.
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While the contribution of system xc− has not been definitively characterized in cerebral ischaemic injury, systemic administration of CPG derivatives has been demonstrated to decrease the infarct volume after MCAO (middle cerebral artery occlusion) in rat (Moroni et al., 2002), a protective effect originally ascribed to inhibition of mGluR1.
This study examined the relative contribution of system failures and extreme behaviour in South Australian crashes as identified from information in Coroner's investigation files and in-depth crash investigations conducted by the Centre for Automotive Safety Research CASRR).
In contrast to the acute retrieval-related effects induced by sleep deprivation, our findings do not point to a critical contribution of system consolidation during post-learning sleep to the generation of false memories.
We perform bifurcation analysis in order to determine the contribution of system parameters to the properties of the three states.
As shown in Figure 1, the cystine uptake in A2780DDP cells was not inhibited at all by arginine indicating no contribution of system b0,+.
Importantly, the effect of starvation was to increase the cotransport of glucose in absence of a contribution of system 2 as expected and confirmed in our studies in mice.
The contribution of system-L and Oatps to murine neuronal T3 transport was only appreciated when the combination of inhibitors BSP + BCH + Prob was found to have an additive and significant effect (34).
Kinetics of l-Arg influx were determined under conditions allowing us to assess the individual contributions of systems y+ and y+L, by selective inhibition of the systems by NEM and leucine, respectively (3). Figure 5 shows that FP impairs the total l-Arg influx in a dose-dependent manner (Fig. 5 A ).
Sensitivity analysis was conducted to investigate the relative contributions of system variables, such as polymer and permanganate concentrations, flow rate, permeability contrast, and different geometry settings.
MSA, explained in more detail under Methods below, tackles the problem of quantifying the relative contributions of system elements (e.g., genes or enzymes) to a given task.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com