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Contribution of inflammation to lung injury and development.
We are specifically examining the contribution of inflammation to the development of pulmonary hypertension.
Del Rio, R., Moya, E. A. & Iturriaga, R. Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia.
We are specifically examining the contribution of inflammation to the development of vascular injury in transplantation, pulmonary hypertension and lymphedema.
To precisely delineate the timing and contribution of inflammation to bronchopulmonary dysplasia (BPD) in preterm infants during the neonatal period.
There is robust information that confirms the enormous contribution of inflammation to plaque development, progression and vulnerability.
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Apart from these direct effects of inflammatory markers on the microcirculation in diabetic nephropathy, little is known about the contribution of inflammation-initiated transmigration of monocytes through the arteriolar wall.
Here, we show that under defined experimental conditions, i.e. pre-activation of the T cells, RNAi technology represents a powerful tool to validate T cell specific genes in murine T cells, which can subsequently be used in established in vivo animal models to better understand the regulation and contribution of inflammation-relevant genes.
Thus the relative contributions of inflammation (local and systemic), stimulus and copy number need to be teased out.
Further studies to dissect the contributions of inflammation, hemodynamics, and local pressure effects on renal injury in IAH are warranted.
As mentioned previously, recent pathologic descriptions of patients with IPF have emphasized the epithelial, mesenchymal, and ECM abnormalities, while de-emphasizing the possible contributions of inflammation to mechanisms of the disease.
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