Sentence examples for contribution of excessive from inspiring English sources

Many studies show that oxidative inactivation can disrupt regulation of transcription and contribute to disease [33], [34], but relatively little information is available concerning the possible contribution of excessive nuclear reduction.

Moreover, because maternal smoking, maternal obesity, and preeclampsia can also cause placental dysfunction and pregnancy complications, it is important to elucidate the contribution of excessive ROS production and increased oxidative stress to proper placental function and pregnancy outcomes.

Because of the epidemics of obesity and diabetes and the possible contribution of excessive television viewing to these conditions, curtailing the quantity of television viewing among children has become a Healthy People 2020 objective [ 12].

To better understand the combined contribution of excessive salt and genetic defects to the etiology of the disease, it is essential to investigate the following question: Question 1: Do variations in genes encoding the IRS -1 and -2 and/or genes encoding the GLUTs proteins predict high salt-induced insulin resistance in Dahl S rats?

Recent evidence has also pointed to the potential contributions of excessive screen time and sleep deprivation to weight problems in children [ 21, 22].

In the 1990's, the "cytokine hypothesis" argued for the detrimental contribution of an excessive production of TNFα to the pathogenesis of HF22, via binding to the TNFR1 receptor subtype, suggesting that TNFα neutralization would be beneficial.

The rrp6-ts32 mutant and rrp6-ts32 cidoubleouble mutant exhibited quite similar transcript patterns, indicating that the contribution of Cid14p to excessive polyadenylation, if any, is probably much smaller than the contributions of Pla1p.

Therefore, biomechanics may explain part of the contribution of the effect of excessive weight on lower extremity symptoms.

In order to reduce excessive contribution of per-location traffic to the network-wide load TaLE also estimates the network-wide load, ω i ℓ, and includes it in the computation of per-location target load.

For instance, it would be interesting to evaluate the contribution of FAPs to the excessive levels of transforming growth factor- β2 (TGF β2), which are induced by elevated canonical Wnt signaling in dystrophic muscles and affect the behavior of SCs.

The relative contribution of systemic factors and excessive biomechanical stress in the association between obesity and OA remains to be elucidated and could be different for different subtypes of OA, such as hand OA versus knee OA.