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However, the contribution of elongation of pre-existing palmitate to the increase in C18 1 synthesis much more pronounced compared to elongation of de novo synthesized palmitate (89 vs. 11%) in high-fat fed mice.
Furthermore, the contribution of elongation of de novo synthesized palmitate to absolute stearate and oleate synthesis was only minor and represented 20 and 9% of the total synthesis, respectively in chow-fed animals.
Moreover our simulations showed a significant contribution of elongation events in buffering the shortening of a long telomere in the presence of telomerase.
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Finally, the mass isotopomer distribution patterns of stearate and oleate were used to calculate the contributions of elongation of de novo synthesized and pre-existing palmitate.
Palmitate synthesis from de novo lipogenesis may however have been overestimated in the current study because we were not able to quantify the contribution of chain elongation to the synthesis of this fatty acid.
Thus, the contribution of translation elongation (ITE) to protein production is much greater than previously documented for this data set, that is, no (Kudla et al. 2009) or less than 3% of the total variation in protein production (Tuller et al. 2010).
Our main goal was thus the identification of factors regulating gene expression and growth in the bovine trophoblast as a major contribution to elongation of the blastocyst before its implantation.
Color key of (B ) is applicable to the color of the interaction lines, the boldness of the arrows indicates individual contribution to elongation rate modulation, and the plusses and minuses indicate a positive or negative effect.
We modified the model introduced by Hellerstein and Neese [14] [16] to determine the contributions of chain elongation of de novo synthesized and pre-existing palmitate to stearate and oleate synthesis.
The relative contributions of spindle elongation, Polo/PP2ACdc55 regulation of Bfa1, Cdc14/Cdk-mediated Cdc15 activation, and possibly additional levels of regulation on the control of MEN activity during anaphase remain to be determined.
Gibbs energies of transfer and adsorption, as well as the average contributions per unit of elongation of the alkyl chain, are estimated and compared to experimental data and empirical results.
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