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Current observations are not sufficient to elucidate or distinguish the contribution of each specific factor.
Additional experiments using mice deficient in ABCB11 and/or ATP8B1 will provide clues about the relative contribution of each specific transporter to statin-induced, miR-33-dependent hepatotoxicity.
The Globaltest (version 5.1.5) [ 24] was used to investigate the contribution of each specific isomir to the differential expression of each miRNA.
As denoted in the previous equation, incorporation of maturational functions such as OSF s) inherently require quantitative CL information regarding the contribution of each specific isozyme in adults.
Compared to allometry, physiology-based CL scaling is computationally complex, requiring predefined knowledge of the contribution of each specific CL pathway in adults as well as quantitative information regarding the pathway ontogeny.
A hierarchical regression modelling strategy was applied by first including socio-economic status (SES) variables, then checking how much variability was accounted for by dental anxiety and SOC, and at the last step, SES, dental anxiety, SOC, and self-reported oral health were included for the full model thereby examining the contribution of each specific measuring area of interest.
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Then, for a pre-specified number, N, of undefined component signatures, NMF finds the N specific signatures and the contributions of each specific signature (the 'pie chart' circle, Figure 5b) that, for all the tumors simultaneously, provide the closest reconstructions of the observed catalogs.
It is shown that the contribution of each system-specific parameter to the developmental changes in clearance is different for morphine and zidovudine.
To understand the contribution of each male-specific isoform to the formation of the male's diverse behavioral repertoire, we constructed flies that carry new isoform-specific knockouts of the fru A and B exons.
Developmental changes in in vivo morphine and zidovudine clearance relative to birth are depicted in Figure 2 for the population models using the semiphysiological glucuronidation function (gray lines) and the PBPK model (black lines), including the individual contribution of each system-specific parameter in the physiologically based model (nonsolid black lines).
The relative contribution (by mass) of each specific chemical was then calculated as the percent (by mass) of each chemical to the total chemical load (by mass).
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CEO of Professional Science Editing for Scientists @ prosciediting.com