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The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine.
Finally, analysis of a cohort of sufficient size to identify common polymorphisms of plausible effect is underway, promising key information regarding the contribution of common alleles to TD.
There was no contribution of common comorbid disorders (depression, alcoholism, generalized anxiety disorder and agoraphobia) in probands on the familial aggregation of either disorder.
There are notable differences in the genetic architecture for different cancer types, with a greater contribution of common variants for prostate cancer.
Previous genome-wide linkage and association studies have not found strong evidence for the contribution of common variants besides the APOE gene, suggesting the role of rare variants in human longevity.
While the contribution of common background factors remains difficult to assess, this study shows that both social causation and health selection are responsible for health inequalities; however, their relative importance changes with age.
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These comparisons support a genetic architecture built from largely polygenic contributions of common allelic variants to dependence on a variety of legal and illegal substances.
Fourth root transformations were made to weigh the contributions of common and rare dietary categories in the similarity coefficient.
Candidate-gene studies have a tendency to lack the power to detect weak genetic contributions of common variants [ 19, 23].
While each study has identified many different loci, these data converge to likely represent true contributions of common allelic variants to polygenic models of genetic vulnerability to polysubstance abuse, and to some psychiatric conditions that share common manifestations (Fig. 4).
They require both high-throughput genotyping platforms and large samples sizes with thousands of subjects from multiple sources and time points to clearly define the contributions of common alleles associated with common complex diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com