Sentence examples for contribution of bid from inspiring English sources

To assess the potential contribution of Bid to DNA damage-induced apoptosis in HeLa cells, we treated HeLa Bid kd cells and HeLa control cells with the anticancer drugs Etoposide (Eto), Oxaliplatin (Ox), and Doxorubicin.

To define the relative contribution of Bid and Bim in paracetamol plus TRAIL induced endothelial cell death, the expression of these pro-apoptotic Bcl-2 homologs was downregulated by RNA interference, as depicted in Supplementary Figure 2. Cell death in response to paracetamol with or without TRAIL was quantified by measuring AnnexinV binding.

To further assess the contribution that regulation of Bid cleavage by Akt has on the Fas-mediated resistance to apoptosis in RA FLS, we used siRNA suppression of Bid.

To assess the relative contribution of the BH3-only proteins Bid and Bim in TRAIL plus doxorubicin-induced cell death, expression of these pro-apoptotic Bcl-2 homologs was reduced by RNA interference, and caspase activation in response to TRAIL, doxorubicin or both was assessed.

To further confirm the importance of Bim and Bid in the contribution of apoptosis sensitivity, we carried out an siRNA approach to knockdown Bim and Bid in the non-HTLV-1-infected T-cell line Jurkat.

Juba, South Sudan, 7 May 2014 – The European Commission, through its Humanitarian Aid & Civil Protection department (ECHO), has announced a contribution of €4.5 million to UNICEF in a bid to scale up the emergency response in South Sudan.

Two different active fragments of Bid have been described: truncated Bid, or t-Bid, [ 27] and j-Bid [ 3].

Alternatively, caspase-8 cleaves BH3-only protein, Bid, to generate the truncated form of Bid, t-Bid [ 31].

Fucoidan induced a significant increase in the protein levels of Bak and truncated Bid (t-Bid), the active form of Bid.

Although no Bid processing was detectable upon stimulation with TRAIL or doxorubicin alone, the combination thereof caused a time-dependent appearance of truncated Bid, suggesting activation of Bid.

Cleavage of Bid (to produce t-Bid) is required for initiation of mitochondrial apoptosis; therefore, elimination of Bid generally inhibits intrinsic and extrinsic apoptosis in hepatocytes.