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We define a notion of soft neighborhood where each gene is given a contributing weight, which decreases with the distance from the candidate gene on the protein network.
Unfortunately, the contributing weight of each gene is not known, making predictions difficult based on gene expression alone of whether proliferation and survival were represented more than cell death in this model of CRPC.
Figure 2 shows the 95% CI of the individual studies and the total result of the four meta-analysed studies together in the mMITT and the PP sets with the contributing weight of each study.
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In order to avoid noise amplification, two types of priors (median and Gibbs type) [14] were included in the IDM, each with a neighbourhood of 1, which could be assigned different contributing weights.
In total, 51 studies contributed weight change data in participants under control conditions (untreated quitters).
In Attributed PPI network I, high-throughput and literature PPI data contribute weights of 0.59 and 0.41, respectively.
111, 112 In humans, ghrelin levels are generally low in obese individuals and increase during weight reduction, potentially contributing to weight regain observed typically after initial weight loss.
Losing out on sleep creates a viscous cycle in your body, making you more prone to various factors contributing to weight gain.
Exenatide slows the emptying of the stomach and causes a decrease in appetite, contributing to weight loss.
The first consideration is whether another AE is contributing to weight loss.
Thus, the need for additional glucose-lowering therapies that can halt β-cell deterioration without contributing to weight gain continues.
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