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Thus, our finding provides new insights into the regulation of altered miRNA expression in contributing to the tumor phenotype.
Impairments of the type I IFN signaling pathway are thought to be the responsible mechanism contributing to the tumor specificity of VSV replication, explaining its attenuated phenotype in PHH when compared to human HCC cell lines [9].
However - presumably by the same mechanisms seen in inflammation-related homing - MSCs are susceptible to becoming encroached by tumors, more specifically so by contributing to the tumor stroma.
Several lines of evidence support the concept that tumor stromal cells are not merely a scaffold, but they rather influence growth, survival, and invasiveness of cancer cells, dynamically contributing to the tumor microenvironment, together with various innate and adaptive immune cells [ 55, 58].
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IL-8 was chosen as a representative chemokine and is responsible for recruiting immune cells to the synovium and contributing to the tumor-like pannus tissue.
4 of the 14 secreted molecules that comprise "tumor-forming" genetic signature according to Milyavsky et al. [ 21], appear as significantly positively contributing to the "tumor-forming" signature.
10 of the 14 secreted molecules that comprise "tumor-forming" genetic signature according to Milyavsky et al. [ 21], appear already at point 6 as significantly positively contributing to the "tumor-forming" signature.
Only 4 of the 14 secreted molecules that comprise "tumor-forming" genetic signature according to Milyavsky et al. [ 21] appear at point 11 as significantly positively contributing to the "tumor-forming" signature.
In 3D-RD, the surrounding activity does contribute to the tumor dose, which is more realistic.
One of the approaches disruptive chemicals contribute to the tumor microenvironment is perturbing energy homeostasis.
Ultrasound combined with liposomes seemed to contribute to the tumor control.
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