Sentence examples for contributing to the transforming from inspiring English sources
Through this interaction, it is proposed that MUC4 serves as a ligand for HER2, resulting in increased phosphorylation of HER2 on the residue Tyr1248 [ 26], which is a major phosphorylation site contributing to the transforming ability of the HER2 oncoprotein [ 29].
The mTORC1 is frequently inappropriately activated in cancer and is contributing to the transformed phenotype [15], and this could play a role in the increased sensitivity of certain cancer cells to TAIII.
In PAX3-FOXO1 expressing ARMS cells, our data indicate that sustained GSK3 β activity represses MYOGENIN function, contributing to the transformed, proliferative phenotype of these cells.
Ras-dependent PI3K activation contributes to the transforming phenotype by mediating anchorage-independent growth, cytoskeletal reorganisation and apoptosis evasion.
PMT-induced expression of the serine/threonine kinase Pim1 caused phosphorylation of SOCS1 and, thus, accumulation of JAK2 and enhanced signaling which might contribute to the transforming capacity of the bacterial toxin.
It is unclear whether an increase in STAT3 mRNA is important for transformation, but it is likely to contribute to the transformed state and the maintenance of STAT3 protein levels.
Up-regulation of fatty acid synthase not only increases production of fatty acids in tumors but also contributes to the transformed phenotype by conferring growth and survival advantages.
Early epigenetic aberrations have been proposed to contribute to the transformed phenotype by promoting the expansion of pre-malignant cells during the earliest stages of tumorigenesis [17], [18].
Here we examined the possibility that CAV1 might contribute to the transformed phenotype of ECC.
Laboratory studies continue to elucidate the key signaling pathways that contribute to the transformed properties of HNSCC cells.
