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If the enzymes responsible for formation of M2 are different from the well characterized conversion pathway of leflunomide to teriflunomide, reduced activity of CYP2C19 is likely to result in increased formation of M2, which may be the toxic metabolite contributing to the side effects associated with leflunomide.
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"It was nice to contribute to the side, to get us back into the game," he said.
Second, a review of other psychotropic medications being prescribed and whether they might contribute to the side effect would be in order.
The larger diameter of the NWs may also contribute to the side growth, since the Gibbs-Thompson effect plays a critical role for thinner nanowires that prevent the sidewall deposition over the course of the growth [47].
In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR.
However, the secondary pharmacology contributes to the side effects that are associated with many pharmaceuticals.
The curtailing of blood flow following enhanced turnover of erythrocytes with increased numbers of phosphatidylserine exposing erythrocytes in circulating blood may contribute to the side effects following uncritical use of erythropoietin or other erythropoiesis stimulating agents [ 55- 57].
The review included 5,500 patients; importantly, 4,000 patients contributed to the side-effect profile.
I find it fascinating and a little frustrating that while directors and conductors often hold directorships and administrative positiions within opera companies, singers themselves rarely have the opportunity to continue to perform while contributing to the other side of the footlights.
Our finding that the mcm4chaos3 allele confers resistance to ciprofloxacin supports our hypothesis that the Mcm2-7 complex is a ciprofloxacin target in cells and suggests that it could also be contributing to the deleterious side effects seen with this class of compounds.
The PL peak is widened by the size dispersion in a sample, with smaller than average CQDs contributing to the short wavelength side of the peak and larger CQDs to the long wavelength side.
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