Sentence examples for contributing to the potency from inspiring English sources

Lastly, enzyme and ligand features contributing to the potency and selectivity differences are analysed by molecular docking.

2) The design of siRNA-encoding libraries precludes mismatches in the RNA duplex, a factor contributing to the potency of endogenous miRNAs.

In addition to the advantages described in the introduction, we have demonstrated herein the importance of mismatches in contributing to the potency of RNA duplexes; the design of the siRNA library precludes mismatches because the siRNAs are encoded by opposing DNA strands and thus are eliminated in E. coli during cloning.

An X-ray crystallography study of NDM-1/B6 complex structure is currently ongoing to investigate the key interactions contributing to the potency.

Together efficacy, toxicity and adherence contribute to the potency of the antiretroviral regimen, where potency is defined as the ability to succeed.

As with compound 8 (Supplementary Figure S3), the P1 ortho-chlorine of compound 16 is also likely to contribute to the potency by accessing the S1 sub-pocket.

Our findings in primary neurons indicated that mitochondrial retention of Smac could contribute to the potency of XIAP in such scenarios.

According to the self-assembly scheme, binding of fondaparinux requires both self-association into hexamers as well as interaction with the pentasaccharide, so both steps contribute to the potency of a given compound.

Taken together, our findings indicate that HDAC inhibitors have an immunomodulatory potential that may contribute to the potency and specificity of these antineoplastic compounds and might be useful in the treatment of autoimmune disorders.

Properties such as absorption, distribution, metabolism, and excretion can clearly contribute to the potency of a congener (Budinsky et al. 2006; DeVito and Birnbaum 1995; DeVito et al. 1997, 2000) and may be misinterpreted when relying solely on intakeTEFs.

Briefly, our findings show that HDACIs have a strong immunomodulatory potential that may contribute to the potency and specificity of these antineoplastic compounds and suggest that the immunosuppressive vs. increased tumor immunity effect of HDACIs might be important for targeting tumor cell proliferation and survival, which may impinge on the future clinical use of these drugs.