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We thank the International Childhood Cancer Cohort Consortium for contributing to the coordination between participating cohorts.
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Compared to the open state, a third tryptophan (W484) has moved in and contributes to the coordination of glycine betaine.
Further this change should not alter the coordination chemistry as it retains the essential chemical feature of site 4, a hydroxyl that can contribute to the coordination shell of the permeant ion [31] (Figure 2C).
ZSL contributed to the coordination.
RM contributed to the coordination and design of the project.
PO contributed to the coordination and design of the project.
FD, AC and VL contributed to the coordination.
PNB contributed to the coordination and conception of this project.
DEJ leads the clinical trial and contributes to the coordination of the implementation.
MT contributed to the coordination of the field evaluation of the software and reviewed the manuscript.
RC contributed to the coordination and design of the study, and the editing of the manuscript.
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