By that time, the sentiments of 90s rave culture the neon, the glowsticks, the faux fur had changed hands as the original raver audience grew up; emerging genres, such as deep house, skewed more to the mature side, contributing to the altering of dance music culture overall.
Notably, constitutively-active Stat3 induces dysregulation of gene expression, contributing to the altered gene expression profile that is a hallmark of cancer.
These signaling pathways activate transcription factor NF-kB, which elicits pro-inflammatory and pro-apoptotic gene expression [14] contributing to the altered cellular function associated with atherogenesis and plaque vulnerability.
Differing activation states can modify macrophage susceptibility to apoptosis [31], but in view of the other features suggesting differences in differentiation we observed it seems that differentiation state, rather than activation state, was the major factor contributing to the altered susceptibility to apoptosis we observed.
Although the specific cell type(s) contributing to the altered gene expression cannot readily be identified, osteoblasts and osteocytes, which represent the most abundant cells in the trabecular bone [ 57], would be expected to contribute significantly to the altered gene expression measured.
However, along with effluxing xenobiotics, members of the ABCB transporter subfamily facilitate plasma membrane transport of IAA [ 78] contributing to the altered IAA homeostasis of epidermal TCs (see Additional file 11 and associated text).
However, the importance of the paper relates more to the use of tools to unravel the sequence of cellular alterations and the interacting modules that contribute to the altered cellular phenotype following MPTP treatment.
Furthermore, the abundance of the index subunit COX1 of complex IV as well as two index subunits (NDUFA9 and NDUFB8) of complex I was decreased in MetR cells (Fig. 5B), whereas subunits of other complexes were unchanged, suggesting that altered stoichiometry of OxPhos complexes may contribute to the altered respiratory profile of MetR cells.
The lower leptin and insulin responses to feeding may contribute to the altered hypothalamic neuropeptide expression after adrenalectomy.
The introduction of bulky substituents at the 20-position contributed to the altered binding mode of the compound by allowing them to form new interactions with Topo I residues.
Although it is known that changes in bone mass, architecture and bone tissue quality occur with age, to what extent they contribute to the altered bone adaptation response remains to be determined.
