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We further used a substructure based approach to understand common substructures potentially contributing to the activity.
Thus, identifying host factors contributing to the activity of pore-forming toxins is expected to identify candidates for new therapeutic approaches.
A similar complexity of interactions between a toxin and a host cell is illustrated by the identification of multiple factors contributing to the activity of the anthrax toxins [59], [60], [61], [62].
The activity of Bmi1(L20A)-Ring1A complex was comparable to the activity of wild-types Bmi1-Ring1A complex suggesting that the E2 binding site on Bmi1 is not contributing to the activity.
Whereas previous studies using a similar approach have emphasized use of hypodiploid cell lines [34], [35], the present study demonstrates that a forward genetic approach may be employed using a common diploid cell line to perform a genome-wide survey identifying mammalian genes contributing to the activity of a bacterial protein toxin.
It is likely that the bridge region would provide enough flexibility for domain cooperativity (inter-domain interaction/s) rather than contributing to the activity of the protein.
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Continue monitoring biotechnology developments with the aim of assessing their possible impact on agricultural commodity markets and contributing to the activities of the Inter-Departmental Working Group on Biotechnology.
Important elements around the active site that contribute to the activity and specificity for mC deamination have been identified for the first time.
Rapalog suppression of HIF1a-mediated transcriptional activation of pro-angiogenic factors like VEGF may contribute to the activity of rapalogs in CCRCCs.
On the other hand, the more strongly bonded species contributed to the activity and to the stability of the catalyst.
The analysis of the structure activity relationship of these compounds could help to elucidate the main molecular features that contribute to the activity of these compounds.
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