The high-temperature area around the magma chamber of Mt. Aso may have contributed to termination of the rupture (Yagi et al. 2016) and high b-values (e.g., Roberts et al. 2015).
Rather, our findings suggest a cooperative effect among multiple elements contribute to termination, with efficiency mediated by redundancy.
The 'torpedo' model of transcription termination, predicts that an exonuclease or helicase enters the nascent transcript at the poly(A) cleavage point and contributes to termination [9].
In order to determine to what degree Xrn2 contributed to termination in our system, we used shRNA to knock down Xrn2 and evaluated the effects in our cell lines.
Based on crosslinking experiments, Rpc37/53 associates with the lobe and external 2 domains of Ret1 (Wu et al. 2011) and contributes to termination (Landrieux et al. 2006).
Overall polymerization rate and/or pausing are thought to contribute to termination by several mechanisms, some of which could be envisioned also to influence the efficiency of poly(A) site recognition and RNA cleavage.
Glucocorticoids are thought to contribute to termination of the initial stress response (Keller-Wood and Dallman 1984) and to participate in long-term restoration of homeostasis triggered by the initial response (Munck et al. 1984).
Consequently, senataxin is an excellent candidate for an alternative protein contributing to transcription termination in human cells.
In particular, fast degradation of odorants in the vicinity of Ors by odorant-degrading enzymes (ODEs) has been proposed as a mechanism contributing to the termination of ORN responses.
