Sentence examples for contributing to more aggressive from inspiring English sources

The ErbB2 gene is amplified in 20 30% of breast carcinomas contributing to more aggressive disease (Slamon et al, 1989).

Three hypothesis were thought for the aberrant expression of maspin in breast cancer cells: maspin gene alteration with loss of activity; a high intracellular density of maspin resulting in auto-inhibition of its function; myoepithelial cell differentiation in cancer cells could contribute to more aggressive phenotype.

Thus, the use of more sensitive imaging in insured populations may contribute to more aggressive immunosuppression.

This event has been hypothesized to contribute to more aggressive forms of ER-positive breast cancer, although this hypothesis remains controversial.

Adenosine was shown to be angiogenic, cyto-protective and anti-inflammatory in several tissues and contributed to more aggressive behavior and metastasis of cancer cells [ 21].

On the other hand, properly extended core m3 glycans may contribute to more aggressive forms of melanomas and can promote the entry of certain arenaviruses into cells.

Additionally, the use of high-dose corticosteroids in the absence of antifungal therapy might have contributed to more aggressive disease progression.

One possible explanation is that the numerous concurrent genetic alterations induced by genome shattering events disturb a large number of genes and contribute to more aggressive tumor phenotypes.

HER-2 (human epithelial receptor 2) is an example of an oncogene that, when activated, contributes to more aggressive behavior in breast cancers.

Notably, DU145R80 cells, compared with DU145 cells, were resistant to spontaneous apoptosis under both adherent and anoikis conditions and acquired an increased invasive capability, suggesting that an extensive ZOL treatment could contribute to more aggressive features in PCa cells.

Furthermore, analysis of data from a pediatric medical center in the United States (30) noted that the rising incidence of antimicrobial-resistant pneumococci corresponded to an increase in suppurative complications of acute otitis media and appeared to contribute to more aggressive infections that required surgical intervention.