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A balance between Rac and RhoA activation is necessary for T cell migratory polarity, with Rac contributing to leading edge formation via actin polymerization, and RhoA together with phosphorylated ERM proteins to uropod formation.
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Leading edge of the lumen intima interface to leading edge of the media adventitia defined cIMT.
In contrast, N-WASP, Scar/WAVE proteins, cortactin and Arp2/3 complex localise to leading edge protrusions of migrating cells, where they contribute to membrane dynamics and protrusion.
All measurements were performed from leading edge to leading edge according to the American Society of Echocardiography guidelines.
In fact, Abercrombie and colleagues showed that a stronger response to the contact is observed with leading edge to leading edge (head-to-head) collisions compared to a leading edge to cell body (head-to-side) (Abercrombie and Dunn, 1975).
The leading edge to leading edge convention was used to measure interventricular septal thickness, left ventricular internal diameter and left ventricular posterior wall thickness.
21 M-mode measurements of left ventricle (LV) dimensions were performed by a leading edge to leading edge technique according to the American Society of Echocardiography guidelines.
This means that different cells contribute to the leading edge before and after ACE (Fig. 10B- 6).
Video 4 Fascin localizes to leading edges of transmigrating protrusions.
Another gene, Mef2a, also contributes to the leading edge set at all ages.
It was determined that Fmn1-IV, as an actin nucleator, contributes to protrusion of the cell's leading edge and focal adhesion formation, thus contributing to cell motility.
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