This study demonstrates that the ligand-based pharmacophore model contributes to efficacy while the structure-based model contributes to specificity.
However, the extent to which the resultant systemic exposure and pharmacokinetics contribute to efficacy depends upon the desired site of action for the molecule.
The physical spaces within which the work of health occurs – the home, the intensive care unit, the emergency room, even the bedroom – influence the manner in which behaviors unfold, and may contribute to efficacy and effectiveness of health interventions.
IsdB induces both humoral and cellular immune responses which may both contribute to efficacy.
Moreover, the fast onset of bronchodilation may improve patient adherence [ 20] and contribute to efficacy.
Any treatment beyond six cycles, however, did not contribute to efficacy assessment.
Autophagy-mediated cell death mechanism contributes to efficacy of anticancer drugs.
Epitope mapping approaches further demonstrated the polyclonal nature of AZD9773 and have started to help us understand which epitopes do and do not contribute to efficacy.
As the elimination half-life (t1/2) of Ki23057 is 93 h on oral administration (Shimizu et al, 2004), orally five times weekly administration of Ki23057 contribute to efficacy.
From a clinical standpoint, the DTG-Gluc metabolite has no antiviral activity and would not contribute to efficacy in the HIV-infected population.
Although the general location of a miRNA binding site within the transcript helps define the degree of repression mediated by miRNAs, other factors contribute to efficacy.
