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These spindles enhance the peroral EPV infection by contributing to disruption of the peritrophic membrane [ 37].
Together, these data suggest that the lysosomal protease levels and thus lysosomal function are impaired at day 1 after SCI, contributing to disruption of fusion and clearance of autophagosomes.
In this scenario, it is tentative to propose that defects in gangliosides synthesis may alter the flow of the lipids through the metabolic pathways contributing to disruption in cellular physiology.
First, glyceraldehyde 3-phosphate dehydrogenase and the α-ketoglutarate dehydrogenase complex were inactivated when cross-linked in vitro to a heterologous protein with expanded polyQ, hence possibly contributing to disruption of cerebral energy homeostasis (Cooper et al, 1997).
Three possible explanations are: (i) haploinsufficiency for another locus (or loci) in the T hp deletion, exacerbating the disruption to XY gonad development; (ii) disruption to a testis-determining gene outside, but close to, the T hp deletion in the form of a position effect or (iii) the presence of the deletion itself contributing to disruption to testis determination.
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PLpro-TM reduces the levels of ubiquitinated forms of RIG-I, STING, TRAF3, TBK1, and IRF3, and contributes to disruption of the signaling required for the induction of IFN.
One of the features of acute renal failure as induced by renal ischemia is the loss tubular epithelial cells (TEC) which significantly contributes to disruption of renal function.
Such a fragment may contribute to disruption of tolerance to fractalkine, resulting in an autoimmune response.
Eliminating DAB2 expression may contribute to disruption of various signalling pathway in NPC.
Rather, it would contribute to disruption of normal APP gene expression that would accompany AD.
24, 25 Ultimately, this contributes to disruption of whole-body insulin sensitivity and impairs glucose homeostasis.
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