"contributing to defective" is not a grammatically correct phrase.
However, "contributing to a defective" or "contributing to the defective nature of" could be used in certain contexts. Example: The lack of maintenance is contributing to the defective functioning of the machine.
This raises the possibility that DNA damage might be contributing to defective osteoblast maturation in the CKO animals (Figure 9B).
The genes contributing to defective placentation are therefore likely to become obvious more quickly.
In parallel, the ectopic accumulation of lipids within muscles renders myocytes insulin-resistant, thus contributing to defective glucose metabolism.
Therefore, α-SNAP depletion could affect Orai1 trafficking to the PM or Stim1 localization in the ER, thereby contributing to defective SOCE.
Cutoffs for both the disease score as well as for the nucleotide variability index were established with the aim to discriminate sequence variants contributing to defective phenotypes.
The past decade has provided significant evidence that complement deficiencies, immunoglobulin (Ig) M deficiency, pentraxin deficiency and defects in macrophage handling may each contribute to defective clearance of apoptotic bodies [ 5- 7].
Things turned ugly, with some saying that this contributed to defective tires.
Statistically significant mutations in KMT2D (also known as MLL2) and HLA-A could contribute to defective immunosurveillance.
ERK phosphorylation is required for development of the lymphatic system33,34,35,55; therefore, reduced ERK phosphorylation induced by tmem33 knockdown may contribute to defective lymphatic sprouting.
Therefore, we suggest that oxidative stress causes nuclear translocation of NF-κB in the renal proximal tubules, which contributes to defective D1 receptor G-protein coupling and function via mechanisms involving PKC, membreceptor G-proteinon of GRK 2, and subsequent phosphorylation of dopamine D1 recoupling
Secondly, since CD146 is expressed on the pericytes (Li et al., 2003; Crisan et al., 2009) and has also been deleted in CD146EC-KO mice (Data not shown), CD146-null pericytes might have contributed to defective tumor angiogenesis.
