Your English writing platform
Discover LudwigExact(8)
It distributes in both spinal and supra-spinal levels, contributing to central sensitization [6].
CGRP might have a pro-inflammatory role in peripheral nervous system by leading to release of pro-nociceptive substances and by facilitating central nociceptive transmission and contributing to central sensitization.
PAG could exert a dual control, including inhibition and facilitation, on nociceptive transmission in the dorsal horn and trigeminal nucleus [8] by descending PAG-RVM (rostral ventromedial medulla) pathway contributing to central sensitization and development of secondary hyperalgesia [8, 9].
PAG, as a substantial descending pain modulatory center, exerts inhibition and facilitation control on nociceptive transmission in the dorsal horn and trigeminal nucleus [4], and the modulatory mechanism was exerted by descending PAG-RVM (rostral ventromedial medulla) pathway contributing to central sensitization and development of secondary hyperalgesia [4, 5].
PAG is a substantial descending pain modulatory center, which exerts a dual control (including inhibition and facilitation) on nociceptive transmission in the dorsal horn and trigeminal nucleus [10], and the modulatory mechanism was exerted by descending PAG-RVM (rostral ventromedial medulla) pathway contributing to central sensitization and development of secondary hyperalgesia [10, 11].
Finally, activation of glial cells with release of pronociceptive mediators can directly modulate neuronal excitability and thus pain transmission, contributing to central sensitization and to the occurrence of neuropathic pain [ 5].
Similar(52)
The United States, Cuba, and the Soviet Union contribute to Central American struggles, making them bloodier and adding to the count of victims without changing the essential outcome.
CGRP also regulates glia activity within the spinal cord and this activity contributes to central sensitization [186].
Cadherins regulate epithelial cell shape and differentiation, contribute to central nervous system (CNS) regionalization, morphogenesis, fiber tract formation and to the maintenance of functional structures.
These results suggest that increased phosphorylation of CREB protein may contribute to central sensitization following acute peripheral noxious stimuli, and the effect may be regulated through the activation of CaM kinase cascades.
Our findings are consistent with the suggestions that AMPA receptors show increased responsiveness because of their phosphorylation and that this may contribute to central sensitization following intradermal injection of capsaicin.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com