The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE.
The characteristics of samples from contributing studies are presented in Supplementary Material, Table S2.
These analyses were conducted on the combined study data as well as separately on the two contributing studies.
With the exception of the female only sample, Project TAAG, the contributing studies collected data on both males and females.
The genotypes of the SNPs comprising the APOE isoforms were in Hardy Weinberg Equilibrium in all contributing studies.
For a variable to be included in the database, it had to be present in at least 3 contributing studies.
20 Tables B-E in appendix 1 on bmj.com provides details of contributing studies, and appendix 2 lists study acronyms.
However, the outcomes we chose had a sufficient number of contributing studies to assess for small differences among the approaches.
Investigators from contributing studies provided HI assay titers, collection date, age, and geographic location at the individual level.
Tools for the de-identification of data were developed, validated and successfully deployed by the contributing studies.
As a result, lower quality variants are less likely to be represented in the credible set than those that are reported in all contributing studies.
