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The quality of the five studies contributing patient level data has been independently assessed in previous systematic reviews.
Table 4 shows the baseline characteristics of the treatment groups in the five studies contributing patient level data.
56 57 Incorporating the results from the current analysis of studies contributing patient level data, treatment of 1000 people with calcium for five years would cause an additional 14 myocardial infarctions, 10 strokes, and 13 deaths, and prevent 26 fractures.
In the five studies contributing patient level data, 143 people allocated to calcium had a myocardial infarction compared with 111 allocated to placebo (hazard ratio 1.31, 95% confidence interval 1.02 to 1.67, P=0.035).
2 3 In a pooled analysis of studies contributing patient level data, 15 21 22 25 28 33 the hazard ratio for fracture was 0.90 (95% confidence interval 0.80 to 1.01) and NNT for five years to prevent one fracture was 39.
Whereas the recurrence risk is generally low in the case of epimutations and UPD, patients/carriers with submicroscopic deletions or duplications might have a 50% risk of conceiving a child with an ID, depending on the sex of the contributing patient.
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CAN-DO IA) study team was responsible for CAN-DO IAing patientstudyteamstudy.
The JOINT members who are contributing patients to the trial are: Robert Balyk, Richard Boorman, Darren Drosdowech, Ken Faber, Steven Gallay, Robert Hollinshead, Richard Holtby, Jordan Leith, Ian Lo, Joe Lobo, Peter MacDonald, Robert McCormack, and Nicholas Mohtadi.
(For details on contributing patients, please contact Karen Clements, Sloane Project Officer. Tel: +44 121 414 7713).
Access to tumor samples was approved by the Tayside Regional Ethics Committee with written informed consent from contributing patients.
Ethical approval was obtained at local ethical committees of centers contributing patients.
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