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Additionally, accumulation of hyperacetylated histones per se is not sufficient to cause growth inhibition (Brinkmann et al. 2001), endorsing the hypothesis that growth inhibition due to HDAC inhibitors is a complex process based upon direct modified gene expression and contributing effects of chromosomal or genomic instability.
The contributing effects of steroid-induced glucose intolerance and dyslipidemia add to the pathophysiology of atherogenesis and prompt continued investigation into more effective steroid-sparing agents and safer approaches to immunosuppression.
Here, we examine the contributing effects of various parameters such as Fe3O4 content, carbonization temperature and thickness on total shielding efficiency (SEtotal) of different samples.
The optimization objective includes the contributing effects of the drilling performance measures: delamination, damage width, surface roughness, and drilling thrust force.
The goal of this study was to examine the contributing effects of prenatal substance use and parenting style (operationalized as contingent responding during the play episodes of the Still-face paradigm [SFP]) on infant affect.
Excessive reliance on oversimplified classification schemes that do not consider all potential contributing effects of a toxicant can obscure the actual causal relationships between exposure and cancer outcome.
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To this purpose, the possibility to profit of the contributing effect of shear walls on the serviceability limit state of the structure is analyzed.
However, we cannot completely exclude the contributing effect of valproic acid.
The use of these techniques by the studies outlined below has allowed for the establishment of a contributing effect of stress on breast tumor growth and incidence.
This is in line with previous knowledge that the contributing effect of adiposity to elevated CRP levels may be especially relevant for women compared to men [ 19].
We agree with the reviewers and we have now incorporated a new section into the Discussion deliberating on a potential contributing effect of changes in DNA methylation due to reduced stability of DNMT1 in the absence of Lsd1.
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