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Complementarily, the progeny of labeled RSCs took 7 days to fill up the CMZ and to start contributing differentiated cells to the layered retina (Fig. 5E,F; supplementary material Movie 2).
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Satellite cells have been shown to be the major contributor to adult myogenesis, and several studies have demonstrated that a subset of satellite cells can self-renew in addition to contributing to differentiated progeny, and thus established their status as adult myogenic stem cells.
This tetrad may contribute to differentiated recognition of effectors by these proteins.
Clones of young and aged cells coexist, but the aged ones do less efficiently contribute to differentiated progeny (Verovskaya et al., 2013).
Thus, the novel prediction we test here is that there will be an association between locus-specific divergence and locus-specific introgression, consistent with highly differentiated loci contributing to reproductive isolation.
While FOXC2 orchestrates the mesenchymal component of the EMT program (Mani et al., 2007), Slug, ZEB2, and Twist1 repress E-cadherin expression, a fundamental event in EMT, as well as the expression of proteins of tight junctions, gap junctions, and desmosomes, contributing to the de-differentiated state of tumor cells and facilitating EMT (Peinado et al., 2007; Sanchez-Tillo et al., 2012).
To a certain extent, our findings for Switzerland can be transferred to other high-income countries and contribute to a differentiated discussion on alcohol tax.
It is now recognized that by enhancing the efficacy and/or tolerability of new drug candidates, nanotechnology can meaningfully contribute to create differentiated products and improve clinical outcome.
Since divergence, cattle types have accumulated different genetic variations, which have contributed to highly differentiated phenotypes.
Remarkably, although similar pathways are up- and downregulated in all aneuploid cell lines, we noticed that the specific factors that significantly contribute to the differentiated regulation are variable.
This reasonable share is what nations owe on the basis of their common but differentiated responsibilities for contributing to climate change.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com