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Despite convincing evidence of the contribution of genetic variation in CDH13 to cardiometabolic traits, the primary causative SNP has not been identified and a multitude of contributing common variants with variable effects across studies has been reported (Fig. 1).
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Rather, he comes to contribute common sense to a crazy environment, made all the crazier by commercial and political pressures".
The extent to which common variants contribute to common phenotypes and disease in humans has important consequences for the future of medical genomics.
Inability to replicate many results has led to increasing scepticism about the value of simple association study designs for detection of genetic variants contributing to common complex traits.
In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS.
The identification of genetic variants contributing to common forms of obesity has been challenging using traditional strategies for selection of candidate genes.
In the past few years, GWASs have identified hundreds of genetic loci contributing to common complex diseases [ 13, 14].
Such studies are particularly useful in finding common genetic variations that contribute to common and complex diseases, such as heart disease, cancer, and diabetes.
Still, if replicated common variation in INSIG2 might, contribute to common forms obesity through interaction with a low level of physical activity.
Both these hypotheses likely contribute to common diseases with genetic variants may range from rare to the common SNPs.
X ≔ people that contribute to common wealth (taxpayers), Y ≔ people that do not contribute (cheaters).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com