Sentence examples for contributes to transformation from inspiring English sources
Whereas in B-cell Non-Hodgkin's Lymphoma (B-NHL) PAG contributes to transformation by maintaining Lyn in an open conformation [ 12].
The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19].
Dysregulated NOTCH receptor activity has been implicated in breast cancer but the mechanisms by which NOTCH contributes to transformation are not yet clear, as it has context-dependent effects on the properties of transformed cells.
These data suggest that the 7q22 CDS contributes to transformation in familial MDS by impairing lymphoid differentiation while also modestly enhancing the growth of GATA2 mutant HSC and their myeloid progeny.
This impaired PRLR turnover, which leads to its stabilization and accumulation, presumably increases the magnitude and duration of PRL signaling and contributes to transformation of human mammary epithelial cells [ 69, 70].
It is possible in ERMS that elevated wild-type PAX7 expression contributes to transformation in the absence of PAX3-FKHR or PAX7-FKHR expression, perhaps by suppressing the apoptotic programme that would normally eliminate these cells (Bernasconi et al, 1996).
The recent evidence that metabolic alteration might contribute to transformation and tumour progression raised interest in anticancer approaches aimed at controlling transformation and metastasization processes6,12,15.
These results demonstrated that transformation of CF was exclusively a biotic process, while abiotic processes contributed to transformation of CT and CFC-11.
