We thus propose that the elevated c-Src activity contributes to the activation of Stat-3 and Fak in ILC cells.
A recent study revealed that both resting microglia and activated microglia after nerve injury express P2X4, P2X7, and P2Y12 ATP receptors [ 18] and that released ATP contributes to the activation of the resting microglia near the activated microglia [ 19].
Ras activates Raf-1 and contributes to the activation of PI3K (with FAK).
(4) We propose that the activity of single, or multiple, NLMS neurons contributes to the activation of small populations of premotor tectal neurons (assemblies).
PI3K catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, activates the downstream Akt, and therefore contributes to the activation of various signaling components involved in the regulation of gene expression and cell survival [ 11].
The activities of MUC1 leading to tamoxifen resistance are many: it contributes to the activation of the PI3K-AKT pathway known to be involved in apoptosis [ 75].
These data indicate that NTG induces oxidative stress, which contributes to the activation of Nrf2/ARE pathway.
The present study was designed to determine whether HGF activates C/EBP in association with the S-phase entrance for cell replication and whether PI3-kinase contributes to the activation of C/EBP.
Additionally, PA contributes to the activation of Akt/phosphatidylinositol 3-kinase (PI3K) signaling by stimulating PI4P5-kinase [24].
Generally, the Hill coefficient increases with the number of serine residues whose dephosphorylation contributes to the activation of NFATc2 [28].
These data demonstrate that MYC contributes to the activation of the ATM-dependent checkpoint responses, leading to cell death in response to specific genotoxic stimuli.
