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The greater space filling function of the naphthyl group, in the context of the other interactions such as the canonical hydrogen bonding with the hinge region, contributes to target affinity and selectivity.
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Thus, AS contributes to targeting mRNAs for NMD [ 14].
By analogy, it could be that a virally encoded product contributes to targeting KAP1 to the HCMV genome.
5' end sequences are critical for miRNA function [2], [41], [71] [73] and the seed region is thought to contribute to target recognition by perfect (or near perfect) complementary binding to the mRNA target site.
Base-pairing elsewhere in the miRNA, including at a so-called T1A site extending the seed region [3] and in the 3' region [3], [4], has also been variously proposed to contribute to target binding.
Together, these observations suggest that cytokines, particularly IFN-alpha, may contribute to target organ damage.
Furthermore, beyond seed site pairing, the centre and the 3′end of the miRNA sequence can contribute to target recognition.
Thus, our data do not support the notion of TiA contributing to target cell resistance in the murine system.
The project aims to contribute to target 17 of the Millennium Development Goals: 'in cooperation with pharmaceutical companies, [to] provide access to affordable, essential drugs in developing countries'.
It is believed that the amphipathic nature of LfcinB allows interaction with the abundant negative charges present in cancer cells, thus contributing to target selectivity [ 34, 44].
This would in turn suggest that they contribute to target specificity, as their sequences are different from the canonical miRNAs from the same pre-miRNAs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com