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Increased expression of TSP-1 on platelets in sepsis presumably contributes to sequestration of platelets and thus the development of the multiple organ dysfunction syndrome [14].
Platelets also are involved in another mechanism that contributes to sequestration and is thought to be important in malaria pathogenesis; platelet iRBC clumping, in which activated platelets and iRBC bind, forming a large cluster of cells that is unable to pass through narrow microvessels and so becomes sequestered.
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In the natural assemblages, mixotrophic algae can contribute to sequestration of carbon, which is otherwise emitted as carbon dioxide to the atmosphere under heterotrophic conditions by other organisms.
It has been postulated that an increase in ultra large VWF strings and a decrease in its cleavage protein ADAMTS13 may result in platelet accumulation and contribute to sequestration of parasitized erythrocytes [23].
A wheat homolog of HMA3 could contribute to sequestration of Cd in root cell vacuoles, limiting radial Cd transport to the stele and subsequent xylem loading.
Therefore it is plausible that ICAM1-mediated cytoadherence has the potential to contribute to sequestration throughout the body during severe malaria.
However, one cannot exclude the possibility that alternative intracellular acidic vesicles such as recycling endosomes, trans-Golgi network and secretory vesicles could also contribute to sequestration of IAs.
Moreover, SOS2 also works to activate and interact with vacuolar N+/H+ and H+/Ca2+ antiporters and V-ATPase, which will contribute to sequestration of excess Na+ ions, further resulting in Na+ ion homeostasis.
Due to its refractory nature and long half-life times, BC contributes to carbon sequestration in soils.
If the cycle 2 kinase reaction is less efficient than the cycle 3 kinase reaction, however, more Y1* will be available to convert Y3 to Y3*, ultimately contributing to the sequestration of more Y3* into a complex with D. Such a sequestration may give rise to a detectable upstream effect as a result of the reduced substrate availability in cycle 3.
Increased expression of endothelial cell adhesion molecules contributes to enhanced pRBC sequestration, leukocyte and platelets adhesion.
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