In roots, RSS3 likely contributes to repress the jasmonic acid response in salt stress conditions to maintain root growth.
These data indicate that E2F7 contributes to repress p21CIP1/WAF1 expression in AML cells.
Thus, whether the nucleolytic processing of the DSB ends contributes to repress transcription around a DSB also in mammals is an important question that remains to be addressed.
However, is it known neither when and how REST contributes to repress direct reprogramming, nor the mechanisms relevant in establishing reprogramming borders during cell differentiation.
This finding indicates that the presence of σ actually contributed to repressing the transcriptional expression of some genes, presumably by competition for shared promoters between σ and σ.
As shown in Fig. 3A, 48 h after transfection with NF90 siRNA, NF90 levels were markedly reduced, while the levels of senescence markers p21, p16, p53 were higher, suggesting that NF90 might contribute to repressing or delaying cellular senescence; nonetheless, by 48 h after siRNA transfection, all of the cells were negative for the activity of the senescence marker ß-galactosidase (not shown).
Most recently, Snail was described to contribute to repress transcription of E-cad gene by binding to the E-boxes of the CDH1 promoter (Giroldi et al, 1997).
Binding, through Rap1, of the transcription factor Fhl1 together with the coactivator Ifh1 to the corresponding promoters activates the transcription of these genes, while other factors, Cfr1, Dot6 and Tod6, Stb3, contribute to repress their transcription.
It is widely accepted that Lin28b overexpression contributes to tumorigenesis by repressing tumor suppressor Let-7 expression in ovarian and other cancers, which is consistent with our view that the PSP94/prostasin pathway may play a key role in the development of several cancer types.
This lysine was shown to be essential for the transcriptional repressive activity of mHES7, using in vitro transcription assays [17], and its absence in mHES6 was suggested to contribute also for the inability to repress transcription [17].
In glioblastoma cells, miR-21 levels are elevated to repress Lrrfip1, contributing to tumor cell resistance to chemotherapy, specifically VM-26 [47].
