The possible relevance of these results in contributing to potency of phage lysins is discussed.
The S3 binding pocket is also well-defined, whereas the S4 pocket is very large and can tolerate a range of capping groups that are likely to contribute to potency by picking up further hydrophobic interactions.
Therefore it is unlikely that this single water-mediated hydrogen bond contributes significantly to potency.
Together efficacy, toxicity and adherence contribute to the potency of the antiretroviral regimen, where potency is defined as the ability to succeed.
Taken together, our findings indicate that HDAC inhibitors have an immunomodulatory potential that may contribute to the potency and specificity of these antineoplastic compounds and might be useful in the treatment of autoimmune disorders.
Briefly, our findings show that HDACIs have a strong immunomodulatory potential that may contribute to the potency and specificity of these antineoplastic compounds and suggest that the immunosuppressive vs. increased tumor immunity effect of HDACIs might be important for targeting tumor cell proliferation and survival, which may impinge on the future clinical use of these drugs.
Profilin is a small actin-binding protein that contributes to the allergenic potency of many fruits and vegetables, including tomato.
Since IL-6 overexpression contributes to the tumorigenic potency of basal cell carcinoma (BCC), this study was designed to investigate whether arecoline altered IL-6 expression and its downstream regulation of apoptosis and the cell cycle in cultured BCC-1/KMC cells.
Studies have shown that DC-derived IL-2 plays a pivotal role in their capability to prime alloreactive T cells [42], [46], and therefore, enhanced IL-2 production in Jak2−/− DCs probably contributes to their unchanged potency to stimulate allogenic or antigen specific T cell activation as well.
Likewise, although the oxime-pyridinium of K027 has a bromide-mediated hydrogen bond to NPhe295 in the K027mAChE crystal structure, it is premature to speculate that this hydrogen bond plays a role in reactivation efficiency or actually contributes to the lower potency of K027 than that of HI-6.
