Sentence examples for contributes to mediating from inspiring English sources
This interaction contributes to mediating the effects of IGFBP-5 on extra-cellular signal-regulated kinase phosphorylation and osteoblast cell proliferation.
This model is supported by the finding that RSK is a substrate of ERK5 (10) and that ERK5 contributes to mediating CREB phosphorylation following neurotrophin stimulation of sensory neurons (12).
To determine whether AR contributes to mediate apoptosis activation in ESC differentiation, TUNEL staining was used to compare apoptosis between ESCs and EBs stably expressing shAR or control shRNA.
Furthermore, knockdown of HO-1 induction obviously increased the DOX sensitivity in MDA-MB-231 cells (Fig. 1c, d), indicating that HO-1 induction contributes to mediate DOX resistance in MDA-MB-231 cells.
GPR120 is known to contribute to mediating the anti-inflammatory actions of polyunsaturated fatty acids (PUFAs) and in protecting against obesity and type II diabetes13,14.
If zTGF-β would have contributed to mediating the invasion and metastatic response we would have also expected elevated pSmad2 staining in the host tissue surrounding the tumour.
Although our findings suggest that DEC1 may contribute to mediating the aggressive phenotype of hypoxic tumours, we did not demonstrate a significant association between DEC1-positive tumours and relapse-free or overall survival that has been reported for hypoxic node-negative and node-positive breast tumours (Schindl et al, 2002; Bos et al, 2003).
This result is consistent with the possibility that Stat5 and Sox6 both contribute to mediate Epo signaling in vivo but act independently of each other rather than cooperatively.
Further, a decrease in troublemaking behavior contributed modestly to mediating the program's association with maltreatment but not neglect.
