Although the N-terminus of Cdc5 is required for its function, how R1, R2, and D3 each contribute to functionality is unclear.
Our identification of domain genetic interactions helps understand how the domains contribute to functionality defined by the SLGIs, and then help elucidate the functional relationships between proteins at domain level from their genetic interactions.
But if this is true for metabolism too, that modularity contributes to both functionality and robustness, then how come there are so many cross-modular couplings?
In vitro and animal studies have confirmed that the production of bacteriocins contributes to probiotic functionality in the GIT.
Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality.
The Mediterranean diet, rich in olive oil, fruits and vegetables, and with a predominance of polyunsaturated fatty acids, also contributes to improved functionality and quality of life in individuals with osteoarticular pathology [ 41].
However, the mutant's reduced mating potencies between day 1 and 3 under both conditions indicate that SIR-2.1 contributes to the functionality of the mating circuits during this period.
Thickness contributes to damage and functionality disruption for most infrastructure (Wilson et al., 2014), is easily measured in the field, and is also an output of some tephra dispersion models (e.g., ASHFALL; Hurst, 1994).
It detected Pli1, a SUMO ligase, suggesting that a component of LinEs, most probably Rec10, becomes SUMOylated and that this contributes to full LinE functionality (Spirek et al. 2010).
Cultural artifacts also contribute to landscape functionality.
Thus, hedgerows potentially contribute to the functionality of these cultural landscapes and provide a basis of important ecological and historical value in landscape conservation planning.
