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Improved health care contributes to declining fertility rates and higher life expectancies, ensuring an older population.
These findings have led to considerable interest and debate about whether exposure to certain environmental chemicals, especially reproductive toxicants, contributes to declining semen quality (Sharpe and Irvine 2004).
Although studies beginning at 15 30 months postpartum have shown that insulin resistance contributes to declining β-cell function after GDM (3, 4), the current data specifically implicate hepatic insulin resistance as relevant to the earlier deterioration of β-cell function in the first year postpartum.
The results raise the possibility that increased body fat contributes to declining β-cell function not only through insulin resistance and increased demands on β-cells (13 , 15, but also through direct effects of circulating adipose tissue peptides on β-cell replication and/or survival.
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Furthermore in the aged, increased cyclooxygenase (COX -2-mediated PGE2 produCOX -2-mediatedes to deCOX -2-mediated-mediated function.
Taken together, it is clear that dampened pErk1/2 pathway likely contributes to declined clonal expansion of aged NSC/NPCs.
Reduced mitochondrial function contributes to decline in glucose uptake with advancing age and leads to insulin resistance [ 93– 93].
Increasing automotive travel such as daily commuting and intercity trucking contributed to declining use of railroads.
I suggest that this extreme politicization is alienating many moderates and contributing to declining movie attendance.
A number of these studies also show that declining rates of observed near-surface u (termed 'stilling') is the primary factor contributing to declining rates of evaporative demand.
Another serious dip in the stock market could contribute to declining spending on drilling in 1988.
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