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This confirms that SF contributes to binding by increasing chloride ion adsorption on the additional C S H produced by the pozzolanic reaction (Luping and Nilsson 1993).
In addition to the well-known nicotinic pharmacophore (positive charge, hydrogen-bond acceptor, and hydrophobic aromatic groups), a hydrogen-bond donor feature contributes to binding of these compounds to Ac, Bt, and the α7 nAChR.
Furthermore, HA Gly239Asn was located on the Ca2 antigenic site that contributes to binding with the host's sialic acid receptor [17].
The structures reveal a shared binding element, Phe76, that contributes to binding as part of both PAM2-N and PAM-C.
Our findings on the functional role of Val-5 are in good agreement with the pepscan analysis of Lajoix and colleagues [37] who found that a Val or Ile at position −5 contributes to binding affinity.
Several hypotheses can be proposed to explain this observation: (1) the FYVE domain is sufficient for endosomal membrane binding but the constructs failed to adopt the appropriate conformation to the bind the endosomal membrane, (2) the FYVE domain is not sufficient and another domain of the protein contributes to binding together with the FYVE domain.
Similar(42)
Therefore, the cysteine residue of the SH3-binding motif of fungal MOB3 proteins conceivably contributes to binding-specificity to a putative SH3-domain protein with a unique function in filamentous ascomycetes.
Such "dissection" of binding into contributions from different groups suggested that the adenine moiety contributed to binding of nucleotide independently of Mg2+ ions.
How does water contribute to binding?
Apart from the base-recognition residue, the other residues in a TALE repeat may also contribute to binding affinity.
In addition to these polar interactions observed in the structure, the N- and C-terminal extensions of ATRXDBM may also contribute to binding with DAXXDHB through electrostatic interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com