Thus, we hypothesized that p53 might contribute to augmented cytotoxicity of 5-FU upon loss of HIF-1α.
In addition, following high-dose prednisolone treatment, FPG levels were, albeit it marginally, increased, which could have contributed to augmented glucose oxidation in the basal state.
Autocrine TNFα production in osteoclasts derived from c/ebpβ−/− or L/L mice indeed contributed to augmented osteoclastogenesis, consistent with earlier reports (Lam et al, 2000; Fuller et al, 2002; Kim et al, 2008).
Whether CGRP directly contributes to the augmented peripheral nociceptive inputs that drive OA pain remains an important unanswered question that has direct relevance to the treatment of pain.
This contributes to an augmented CO2-chemosensitivity [ 10– 14] resulting in chronic hyperventilation with hypocapnia [ 13, 14], enhanced ventilatory response to exercise with inefficient ventilation (VE/VCO2-slope), and exertional oscillatory ventilation (EOV) [ 15].
Taken together, our experiments reveal for the first time that IL-6 increases ABCG2, anti-apoptotic protein expression, and contributes to IL-6 augmented lung cancer chemotherapeutic resistance by activating the ATM and NF-kappaB pathways, indicating that ATM and IL-6 are potential targets for managing lung cancer chemotherapeutic resistance.
There are two terms contributing to the augmented travel time [Eq. (13)]: normal or cruise travel time ( (t_{a} ) ) and beta ( (beta_{a} ) ).
Alternatively, an activation of matrix-bound aggrecanases by SFB-derived MMP could contribute to the augmented aggrecanase activity in co-culture [ 39].
IL-17A was expressed after O3 exposure, especially in the obese mice, and could also contribute to the augmented O3-induced AHR observed in these mice.
39 Increased TrkA expression by sensory nerves innervating the osteoarthritic knee may contribute to the augmented weight-bearing asymmetry following intra-articular injection of NGF.
