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1, 11, 12 It was hypothesized that diminishing the pre-OB pool with sclerostin inhibition contributes to attenuation in bone-formation activity after multiple doses.
The σ global regulon of S. Typhimurium LT2 may differ from that of virulent S. Typhimurium isolates due to accumulated mutations in this extensively-used, laboratory strain, particularly the rpoS mutation that contributes to attenuation of the LT2 strain [ 42].
However, a downside of multiple extraction is that it increases the residual macromolecular concentration (see Figure S6 in the Supporting Information), which apart from distorting the baseline, contributes to attenuation of the reference compound, TSP, which is detrimental to accurate quantitation if not corrected suitably.
Similar(57)
We choose point source because it is easy to focus and contribute to attenuation measurement.
Furthermore, reduced induction of proinflammatory cytokines by both bcr1Δ and als3Δ might also contribute to attenuation.
Thus, downregulation of these genes in the phoP mutant could contribute to attenuation.
Therefore, the reduction in YopE and YopH synthesis observed in the ΔrelA ΔspoT mutant may also contribute to attenuation.
Of the 171 genes less common in complicated infections, 152 are of unknown function and may contribute to attenuation of virulence.
Moreover, β-lactams have been reported to directly bind to IFNγ and other cytokines and inhibit their activity [41], [42], [43], an effect that might contribute to attenuation of EAE by ceftriaxone in vivo.
Clearly, the loss of the ability to select the port of entry and the possible unspecific interactions with the membranes of the internal compartments where Brucella multiplies are factors that can contribute to attenuation.
This could contribute to attenuation of estimates in low PSI group.
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