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Despite advances in complex disease genetics, remarkably little attention has been paid to whether genetics contributes to aspects of disease biology beyond simple susceptibility.
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Previously, we reported that the PKA pathway contributed to aspects of neural differentiation of MSChUCB [6].
It cannot be excluded that altered FMR4 expression might contribute to aspects of the clinical presentation of fragile X syndrome and/or related disorders.
Whether these also contributed to aspects of the B cell repertoire cannot be assessed as the medication regimens in our patient cohort were too varied.
CF also contributed to aspects of the analytic approach.
All authors contributed to aspects of the study design.
GBB contributed to aspects of the analyses and contributed to the preparation of the manuscript.
Both MR and JD contributed to aspects of the data collection and validation, and literature review.
All authors contributed to aspects of the design and planning of the systematic review.
VS, KS and MS serve as research coordinators, blinded evaluators and contributed to aspects of the protocol design.
AC, DR and MP wrote the manuscript, DP contributed to aspects of the writing of the manuscript.
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