It was also assumed that the maintenance of ATP stores might contribute to a switch of cell death from necrosis to apoptosis, as apoptosis has been associated with higher ATP content compared to necrotic cell death.
Here we show that the gastric environment can contribute to a switch in Lewis phenotype in the two experimental mouse models.
Such genetic and epigenetic events may contribute to a switch from a normal developmental program in adult cells during the formation of diseased tissues, including cancers.
It is plausible that in the event of chronic damage or stress, DBC1 plays a role in checkpoint control, contributing to a switch in cell fate and promoting cellular senescence.
An interesting possibility is that Dom functions at both inactive and active E2F target promoters, potentially contributing to a switch between negative and positive regulation of transcription and cell division.
Persistent EGFR signaling, coupled with the autocrine induction of membrane-bound HRG, contributed to a switch in the regulation of cell survival from HER2-HER3-PI3K in treatment-naïve HER2+ breast cancer cells to an HRG-driven EGFR-HER3-PI3K-PDK1 sinnaling axis in lapatinib-resistant tumor cells.
These data demonstrate that increasing amount of NMDA activated more receptors, which contribute to a program switch from survival to cell death.
According to a 2011 article in The Ergonomics Open Journal, electronic communication tools can demand constant switching, which contributes to a feeling of "discontinuity" in the workplace.
Model predictions indicate that the transition from high to low runoff coefficients in the Blue River basin is linked to variations of water table depth and surface soil moisture, contributing to a seasonal switching of surface runoff generation mechanisms, from saturation excess to infiltration excess.
Our analysis demonstrates that two independent positive feedback loops in the Bcl-2 network contribute to an inherent switch to govern apoptosis decision.
