This suggests that FAC alters autophagy in an ATG5/ATG7-dependent and a Ras-independent manner, which contributes only a modest effect to FAC-induced cell survival implicating other mechanisms in modulating FAC-induced cell death response.
Our identification of an SAID-associated profile of genes influencing multiple molecular pathways, including the immune response, cellular signaling, inflammation, transcriptional/translational, and other regulatory controls, is consistent with GWASs demonstrating large numbers of genetic susceptibility loci, each of which contributes only a modest degree of overall risk [ 26, 28, 29].
Gaumont, which gave its imprimatur and distribution network, contributed only a modest amount of money, and French television channels, which normally help finance French films, all declined to touch "La Conquête," all except the paid cable channel Canal Plus, Mr. Altmayer said.
Although the observed two-fold decrease in risk is modest, our finding is intriguing because genes in multiple pathways alter the risk for hepatocellular carcinoma, and each individual gene is likely to contribute only a modest risk.
Though the observed two-fold decrease in risk is modest, our finding is intriguing because genes in multiple pathways alter the risk for HCC, and each individual gene is likely to contribute only a modest risk.
Finally, it should be noted that, while there was increased risk of subsequent cancer associated with women assessed at first screen, such women contributed only a modest proportion of all interval and second round screen-detected cancers.
This empirically modest correlation suggests that short-term PM exposure contributes only a small portion, if any, of the overall inflammatory response to long-term repeated PM exposure.
Although each of genes involved in the serotonergic system may contribute only a small to modest effect, their co-contribution with the environment or other genetic or epigenetic factors may result in BPD.
Second, we assessed only the common variation within the NFE2L2 gene, and they would contribute to an explanation of only a modest fraction of the genetic component of the syndrome.
Our data show that the PRD of HTT exon1 beyond the first 10 prolines contributes only modest quantitative differences in some biophysical properties, while other properties seem to be essentially unchanged.
Despite the implications that epistasis may be important, the available data thus far suggest that most gene interactions are merely additive [ 114] and where multiplicative interactions exist they only contribute a modest effect for prostate cancer [ 115] and for breast cancer [ 116].
