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For example, in Figure 1A, category 6, the retrocopy contributes in-frame protein coding region (magenta) combined with unannotated intergenic sequence (dark blue) to form a new N-terminal encoding exon for the host gene.
E) The RPL7A-derived retrocopy contributes half of the ORF in-frame (magenta) and half out-of-frame (dark red) yielding novel gene candidate Q9BR82.
Moreover, with telomerase upregulation, the switch to NMD-sensitive transcripts may contribute to downregulation of the in-frame isoform acting as a negative regulator.
2) Retrocopy contributes new 3' exon to host gene (mostly in-frame, magenta, and partially out-of-frame, dark red, with respect to parent gene).
The 1500 fusions from normal tissue contribute to the negative set and provide both in-frame and frame-shifted fusions.
The notion of sharks as fearsome predators, cultural representation in movies such as Jaws, plus sensationalist media coverage of shark attacks all contribute to frame sharks negatively in the public imagination.
IF: in-frame, FS: frame-shift.
* Get the full dish in frame.
Shift in frame of reference.
IF/OF: in frame or out-of-frame.
Everything is located in frame.html.html
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